The research team of Professor Laura Machesky is seeking to recruit a postdoctoral fellow with a background and interest in cancer research and cell biology for a multidisciplinary project.
The candidate would join an international team of biologists studying cell migration, mechanosensing and the molecular mechanisms of cancer metastasis. This project is funded by Cancer Research UK as a part of a programme investigating how the microenvironment contributes to progression and metastasis of pancreatic cancer. We are interested in how the stresses of the microenvironment- such as changes in the mechanical properties of the matrix and starvation for nutrients can drive cancer cells to become more aggressive. We are also studying how cancer cells can fuel their survival and migration even in nutrient poor conditions using macropinocytosis to switch to alternative nutrient sources. Macropinocytosis also regulates signaling, via trafficking of surface receptors on cells. Many cancer types show enhanced macropinocytic uptake, which is driven by enhanced RAS signaling and in particular, KRAS, which drives the vast majority of pancreatic cancers.
Fixed-term: The funds for this post are available for 36 months in the first instance.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
For informal enquiries can be sent to Karen Condie: lmm202sec@bioc.cam.ac.uk
For any questions about this vacancy or the application process please contact: personnel@bioc.cam.ac.uk
Close 10 April