AZ funded non-clinical PhD studentship -Experimental computational framework for optimising dosing strategies (apply by 14 Nov)

AZ funded non-clinical PhD studentship - Experimental and computational framework for optimising dosing strategies to mitigate T-cell exhaustion in T-cell engager therapies.  T-cell engager (TCE) therapies are increasingly prevalent in the clinical pipeline of pharmaceutical companies. While TCEs are promising therapeutic agents due to their high potency, a major pitfall is T-cell exhaustion, which reduces therapeutic effect of TCEs so preventing rapid regression of the tumor lesion. In this project you will evaluate the concept of "dosing holidays" and how they may mitigate T-cell exhaustion.

You will combine interdisciplinary approaches of extensive in-vitro experiments that quantify effector cell kinetics with translational pharmacokinetic pharmacodynamic modelling to inform, evaluate and design potential schedules to mitigate T-cell exhaustion.

Application process: Apply for a PhD in Pharmacology via the University's Applicant Portal (https://www.postgraduate.study.cam.ac.uk/courses/directory/blphpdphc/apply).

For informal enquiries, contact Prof Graham Ladds (grl30@cam.ac.uk), or Postgrad@phar.cam.ac.uk for questions about the application process.