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Engineering Biology in Cambridge

 

EngBio ECR Meet, Greet & Talks

EngBio ECRs (formerly EngBio Postdocs) is a initiative to help connect postdocs and postgrads across the university. We will be hosting regular events where you can meet and network with other postdocs from across university departments, as well as supporting early career researchers to pursue their own projects and initiatives.

Postdocs, research and support staff and graduate students are welcome from across the University and University-affiliated institutes (MRC-LMB, Babraham Institute etc.).

You can sign up to join the EngBio Postdoc community and receive notifications about events and opportunities using the Join Us Form.

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Next Meeting: 17 June 2024, 12pm-1pm at Postdoc Centre, Basement, 16 Mill Lane. 

Sign Up HERE  or email vr314@cam.ac.uk

This month's talks featuring:
Rui Guan, MRC Toxicology
Pehuen Pereyra Gerber, Dept. Medicine

Sign Up here on MEETUP or  email vr314@cam.ac.uk

 

Title: Genetic landscape of prevalent gut commensal Bacteroides uniformis

Rui Guan, MRC Toxicology

The gut microbiome plays a critical role in human health, yet its evolutionary trajectory remains challenging to understand due to its complex composition. In this study, we investigate the genetic landscape of one of the most prevalent gut bacteria, Bacteroides uniformis, across different human populations. By analyzing publicly available datasets, we identified highly diverged genes and non-coding regions within each cohort. Our study aims to deepen the understanding of the gut microbiome's adaptation and the complex environment-gut-microbe interactions through the lens of evolution.

Title: Development of a SARS-COV2 reporter cell line for high-throughput analyses of viral infection

Dr. Pehuen Pereyra Gerber, Research Associate - Matheson's Lab, Cambridge Institute of Therapeutic Immunology and Infectious Disease

Abstract: At the onset of the COVID-19 pandemic, a simple, scalable, and standardised assay for SARS-CoV-2 infection and antibody neutralisation was lacking. Plaque assay - the gold standard method- is impractical for high-throughput analyses. We showed that viral proteases can be used to quantitate infected cells in an assay that exploits the cleavage of specific oligopeptide linkers to activate an optical biosensor. Taking advantage of this, we generated a luminescent SARS-CoV-2 reporter cell line that enables viral infection to be measured within 24h in a 96- or 384-well plate format, including variants of concern. In this talk, I will highlight key aspects of this development and how we have applied it in numerous collaborative projects. 

 

Future Dates:

Monday 15 July

 

Previous Meets

  • 18 March Marion Short, Chemistry "Microbial Electrosynthesis for CO2 Conversion to Acetate"  & Soleh Anderlini, Dept. Chemistry. “Plastic-eating” bacteria: challenges with Ideonella sakaiensis and its’ PET-digesting enzymes.
  • 19 February "Curing plasmids for restoring antibiotic sensitivity in vivo" Alma Wu, Dept. Engineering (Bakshi Lab) and ‘A modular toolset for electrogenetics’Joshua Lawrence, Dept. Chemistry
  • 22 January “A microfluidics-enabled workflow for rapid large-scale sequence-function mapping informs biocatalyst engineering” Maximilian Gantz, Dept. Biochemistry
  • 11 December "Production of nanobodies in Marchantia polymorpha"  Anna Sze Wai TSE, PhD student, Haseloff Lab, Department of Plant Sciences 
  • 20 November, Talks by Charlie Wedd, Engineering "Measuring the kinetics of phage infection steps with single-cell microscopy" and “Engineering a photo-active enzyme for organic decarboxylations” Irina Gostimskaya, Dept. Chemistry.
  • 16 October, Talks by Guillermo Serrano Najera, Dept. of Genetics and Georgeos Hardo, Engineering.
  • 18 September, Aaran Vijayakumaran, MRC Toxicology Unit.
    'The Nanoscale Architecture Of The Airway Epithelium By Volumetric EM, Deep-Learning Segmentation and Super-Resolution Imaging.'
  • 17 July, 12pm-1pm  Layla Malouf, Dept of Chemical Engineering & Biotechnology. Title: Building synthetic cells using DNA nanotechnology.
  • 19 June, 12pm-1pm  Devmalya Sarkar, Insitute of Manufacturing.  Title: ‘App’reciating User Needs: early-stage user involvement in need identification for user-centric health apps
  • Monday 15 May MRC Laboratory of Molecular Biology (LMB)  12pm-1.30pm.  MRC LMB Talks and Tour,  Edoardo Gianni, PhD Talk Title: Engineering a self-replicating RNA machine
  • Monday 17 April, 12pm-1pm. Postdoc Centre, Mill Lane. Dr Nikolai Kazantsev  ‘Rapid Response Capability to Future Disruptions: A Consortium Network Case’
  • Monday 20 March, 12pm-1pm Postdoc Meet and Greet at Dept. Chemical Engineering and Biotechnology (CEB), Philippa Fawcett Drive, West Cambridge Site CB3 0AS.
  • Monday 20th February 2023 12pm-1pm - Dr Jenny Molloy will host a meet and greet.