The Cambridge iGEM team won a Gold Medal and received a nomination for the ‘Best Hardware’ special prize in the Undergrad Category at the 2024 iGEM Grand Jamboree. Their project ‘MaGenTa’ worked on developing tools for magnetogenetics, an approach using magnetic fields to remotely and precisely control gene activation.
iGEM is the world’s largest synthetic biology competition and community. Each year thousands of students, representing teams from over 400 universities worldwide, work on projects in the lab to solve real-world problems using Synthetic Biology.
Meet the Team
This year, the Cambridge team comprised an interdisciplinary group of 9 undergraduate students, supported by an Instructor and Advisor Team formed of PhD Students and iGEM Alumni. Team members came from a variety of backgrounds: Holly Bristow (1st year Natural Sciences), Will Cassie (1st year Natural Sciences), Linhan Lei (1st year Natural Sciences), Lisa Milne (1st year Engineering), Gus Molyneux (3rd year Engineering), Dhriti Rao (3rd year Genetics), Jamie Terry (1st year Chemical Engineering and Biotechnology), Cenyujia Wang (1st year Natural Sciences), Roger Wang (1st year Natural Sciences).
Figure 1: The 2024 Cambridge iGEM team outside St John’s College
MaGenTa: Biological and Hardware Tools for Magnetogenetics
Their project was in the field of magnetogenetics, which makes use of magnetic fields to control gene expression. While spatiotemporal control of gene expression is crucial for many fields, such as neuroscience and organoid research, current methods are limited by factors such as cost and penetration depth. The team believes that a magnetogenetics approach could help overcome these limitations, and aimed to develop a set of biological and hardware-based tools that would allow precise control of gene expression using magnetic fields, with their efforts earning them a “Gold Medal”
Figure 2: A look inside the MaGenTa hardware
They were also nominated for the “Best Hardware” special prize, in recognition of their system that allowed the movement of electromagnetic coils around a plate of cells and an imaging system to capture fluorescence and heat information. This hardware drew a lot of excitement when presented at both the Cambridge MakeSpace and the iGEM Jamboree. While the project was quite foundational, the team met with experts in various fields where they felt it could be applied, such as neuroscience and oncology, to ensure that key features for application (such as spatial resolution and toxicity) were considered throughout.
Further Information
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References and Links
The team’s wiki, documenting their work on the project: https://2024.igem.wiki/cambridge/
The team’s presentation video summarising the project details: https://video.igem.org/w/dRyn1DWzEv35vaCsxJFk4M
Author Information
Dhriti Rao,
Kavi Shah, Department of Genetics, University of Cambridge
Credits and Acknowledgements
The team is incredibly grateful for sponsorship from university-affiliated bodies, the School of Biological Sciences, Department of Engineering, SPIP, C2D3 Computational Biologyand EngBio IRC, as well as from companies MicroMod, NEB, Beckman Coulter, and BMG LabTech.
The team would also like to thank the team of instructors that advised them throughout the project: Kavi Shah, Chi Ki Leung, Jarrod Shilts, Georgeos Hardo, Sharon Ho, Johann Sora Blakytny, Kieran Abbott. They also thank the Department of Engineering, Dr. Somenath Bakshi and Mr James Macleod for providing lab space.