An exciting opportunity is available for a Postdoctoral Researcher to join the group of Prof. Jake Harris at the Department of Plant Sciences. The laboratory is situated on the Downing Site in Cambridge and houses state-of-the-art facilities. The project is part of a pioneering new effort to generate fully synthetic plant chromosomes, funded by the Advanced Research + Invention Agency (ARIA: https://www.aria.org.uk/opportunity-spaces/programmable-plants/synthetic-plants). To develop the critical capabilities required, the primary model organism that the candidate will be working with is the so-called 'green yeast', Physcomitrium patens, with potato as the ultimate end-goal for delivery. There are many unique advantages to Physcomitrium for plant synthetic biology, including highly efficient homology-directed repair. The project will involve a range of genomic and molecular biology approaches, from developing epigenetic insulator systems, epigenome profiling and CRISPR-based epi-engineering, to long-read sequencing, karyotyping, and live-cell imaging. The project is part of an integrated team effort involving academic and biotech laboratories across the UK and Australia.