Applications are invited for a Research Associate position in the group of Dr Alexander Jones at the Sainsbury Laboratory, Cambridge University. Applicants must have or be close to obtaining a PhD in Plant Biology, Biochemistry, Systems Biology, Genetics, or related field. Where a PhD has yet to be awarded the appointment will initially be made at Research Assistant level (Grade 5) and amended to Research Associate (Grade 7) upon the award of PhD.
The cellular dynamics of the plant hormones underpin all aspects of plant development and environmental responses. Targeted perturbations of phytohormones such as abscisic acid and auxin have great
potential to reprogram plant development. The project involves two aims: (1) discovery of how plant hormones respond to environmental stresses that are expected in the more extreme climates of the future and (2) redesigning root development via fine-scale perturbations of hormone dynamics with minimal off-target effects. The Jones group at SLCU has recently engineered a series of high-resolution FRET biosensors to track such dynamics for gibberellin, abscisic acid, auxin and salicylic acid in living plants.
The Jones group combines imaging of FRET biosensors with high-resolution genetic and biochemical perturbations to understand phytohormone cellular dynamics. This post will involve use of existing plants expressing biosensors to illuminate previously undetectable cellular and subcellular hormone patterns in vivo. The project's outcomes will be a mechanistic understanding of how and why hormone accumulations or depletions are modulated in space and time and application of this understanding to reprogram root developmental plasticity. We also collaborate with mathematicians to build multi-scale understanding of these complex and important signaling pathways.