Dr Mousumi Shyam
Postdoctoral Researcher
Department of Medicine
Biography
I'm a chemical-biologist in the broad domain of mycobacterial infections, with a focus on the tuberculosis causing pathogen, Mycobacterium tuberculosis.
Interested in understanding the reason behind genetic evolution and the quick drug resistance nature of pathogen. Particularly, the idiosyncratic nature of pathogen resulted in the imminent loss of the therapeutic life span of all established antibiotics as well as the newer discoveries in the drug market. My keen interest in solving global challenges like antibiotics-resistance by performing cutting-edge interdisciplinary research always keeps me motivated to come up with ingenious solutions for the global community. I have a stout inclination towards understanding and developing newer expertises to contribute significantly to the TB Drug Discovery and Development Horizon.
Research
I am particularly interested in understanding bacterial permeability, accumulation, efflux and metabolism of drug-like molecules and how understanding these processes can lead to the development of predictive models, using machine learning methods, that can guide rational antibiotic development. I am further interested in understanding how bacterial metabolism of antibiotics affects their efficacy, how antibiotic interactions modulate bacterial drug metabolism, efflux and retention and how understanding these processes can lead to improved antibiotic combinations.
