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Engineering Biology in Cambridge


The theme of our group's research is innovating protein technologies for therapeutics and vaccine design. Inspired by extraordinary molecular features from the natural world, our research develops new approaches for disease prevention and therapy. By engineering and evolving proteins and cellular systems, our projects range from fundamental analysis of protein interactions through to clinical application. Please see for further information. 




Key publications: 

SpySwitch enables pH- or heat-responsive capture and release for plug-and-display nanoassembly. 

Vester SK, Rahikainen R, Khairil Anuar INA, Hills RA, Tan TK, Howarth M. Nature Communications 2022 Jun 28;13(1):3714.  


Gastrobodies are engineered antibody mimetics resilient to pepsin and hydrochloric acid. 

Wicke N, Bedford MR, Howarth M. Communications Biology 2021 Aug 11;4(1):960. 


NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins. 

Scheu AHA, Lim SYT, Metzner FJ, Mohammed S, Howarth M. Nature Communications 2021 Jan 29;12(1):717. 


Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice. 

Cohen AA, Gnanapragasam PNP, Lee YE, Hoffman PR, Ou S, Kakutani LM, Keeffe JR, Wu HJ, Howarth M, West AP, Barnes CO, Nussenzweig MC, Bjorkman PJ. Science 2021 Feb 12;371(6530):735-741.


Overcoming Symmetry Mismatch in Vaccine Nanoassembly through Spontaneous Amidation. 

Rahikainen R, Rijal P, Tan TK, Wu HJ, Andersson AC, Barrett JR, Bowden TA, Draper SJ, Townsend AR, Howarth M. Angewandte Chemie 2021 Jan 4;60(1):321-330. 


Sheild Chair of Pharmacology

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Takes PhD students
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